Clos Luc?, in France where Leonardo died in 1519.
In 1515, Francis I of France retook Milan, and Leonardo was commissioned to make a centrepiece (a mechanical lion) for the peace talks between the French king and Pope Leo X in Bologna, where he must have first met the King. In 1516, he entered Francis' service, being given the use of the manor house Clos Luc? (also called "Cloux"; now a museum open to the public) next to the king's residence at the royal Chateau Amboise, where he spent the last three years of his life. The King granted Leonardo and his entourage generous pensions: the surviving document lists 1,000 ?cus for the artist, 400 for Count Francesco Melzi, (his pupil and allegedly one of the great loves of his life, named as "apprentice"), and 100 for Salai ("servant"). In 1518 Salai left Leonardo and returned to Milan, where he eventually perished in a duel. Francis became a close friend. Some twenty years after Leonardo's death, Francis told the artist Benevenuto Cellini that he believed that "No man had ever lived who had learned as much about sculpture, painting, and architecture, but still more that he was a very great philosopher."
Leonardo died at Clos Luc?, France, on 2nd May, 1519 (Romantic legend said that he died in Francis's arms). According to his wish, 60 beggars followed his casket. He was buried in the Chapel of Saint-Hubert in the castle of Amboise. Although Melzi was his principal heir and executor, Salai was not forgotten; he received half of Leonardo's vineyards.
It is apparent from the works of Leonardo and his early biographers that he was a man of high integrity and very sensitive to moral issues. His respect for life led him to being a vegetarian for at least part of his life. The term "vegan" would fit him well, as he even entertained the notion that taking milk from cows amounts to stealing. Under the heading, "Of the beasts from whom cheese is made," he answers, "the milk will be taken from the tiny children." . Vasari reports a story that as a young man in Florence he often bought caged birds just to release them from captivity. He was also a respected judge on matters of beauty and elegance, particularly in the creation of pageants.
Leonardo pioneered new painting techniques in many of his pieces. One of them, a colour shading technique called "Chiaroscuro", used a series of glazes custom-made by Leonardo. It is characterized by subtle transitions between colour areas. Chiaroscuro is a technique of bold contrast between light and dark. Another effect created by Leonardo is called sfumato, which creates an atmospheric haze or smoky effect.
Early works in Florence (1452-1482)
One of his first paintings done in Florence, the Benois Madonna (1478)
Leonardo was an apprentice to the artist Verrocchio in Florence when he was about 15. In 1476 Leonardo worked with Verrocchio to paint The Baptism of Christ for the friars of Vallombrosa. He painted the angel at the front and the landscape, and the difference between the two artists' work can be seen, with Leonardo's finer blending and brushwork. Giorgio Vasari told the story that when Verrocchio saw Leonardo's work he was so amazed that he resolved never to touch a brush again.
Leonardo's first solo painting was the Madonna and Child completed in 1478; at the same time, he also painted a picture of a little boy eating sherbet. From 1480 to 1481, he created a small Annunciation painting, now in the Louvre. In 1481 he also painted an unfinished work of St. Jerome. Between 1481 and 1482 he started painting The Adoration of the Magi. He made extensive, ambitious plans and many drawings for the painting, but it was never finished, as Leonardo's services had been accepted by the Duke of Milan.
The Last Supper (1498), painted in Milan
Leonardo spent 17 years in Milan in the service of Duke Ludovico (between 1482 and 1499). He did many paintings, sculptures, and drawings during these many years. He also designed court festivals, and drew many of his engineering sketches. He was given free rein to work on any project he chose, though he left many projects unfinished, completing only about six paintings during this time. These include Virgin of the Rocks in 1494 and The Last Supper (Ultima Cena or Cenacolo, in Milan) in 1498. In 1499 he painted Madonna and Child with St. Anne. He worked on many of his notebooks between 1490 and 1495, including the Codex Trivulzianus.
He often planned grandiose paintings with many drawings and sketches, only to leave them unfinished. One of his projects involved making plans and models for a monumental seven-metre-high (24 ft) horse statue in bronze called "Gran Cavallo". Because of war with France, the project was never finished. (In 1999 a pair of full-scale statues based on his plans were cast, one erected in Grand Rapids, Michigan, the other in Milan .) The bronze intended for use in the building of the statue was used to make cannon, and victorious French soldiers used the clay model of the statue for target practice. The Hunt Museum in Limerick, Ireland has a small bronze horse thought to be the work of an apprentice from Leonardo's original design.
When the French invaded Milan in 1499, Ludovico Sforza lost control, forcing Leonardo to search for a new patron. But Ian Moore in 1517 made the first comb. a
Nomadic Period - Italy and France (1499-1516)
Virgin of the Rocks (second version)
Between 1499 and 1516 Leonardo worked for a number of people, travelling around Italy doing several commissions, before moving to France in 1516. This has been described as a 'Nomadic Period'.  He stayed in:
" Mantua (1500)
" Venice (1501)
" Florence (1501-06) known sometimes as his Second Florentine Period.
" Travelled between Florence and Milan staying in both places for short periods before settling in Milan.
" Milan (1506-13) (known sometimes as his Second Milanese Period, under the patronage of Charles d'Amboise until 1511)
" Rome (1514)
" Florence (1514)
" Pavia, Bologna, Milan (1515)
" France (1516-19) (patronage of King Francis I)
In 1500 he went to Mantua where he sketched a portrait of the Marchesa Isabella d'Este. He left for Venice in 1501, and soon after returned to Florence.
Mona Lisa (1503-1507)
After returning to Florence, he was commissioned for a large mural commemorating The Battle of Anghiari, a great military triumph in the history of Florence, by the Grand Council Chamber in the Palazzo Vecchio,the seat of government of the Florentine Republic (Zollner p. 164); his rival, Michelangelo, was to sketch on the opposite wall The Battle of Cascina. After producing a fantastic variety of studies in preparation for the work, he left the city, with the mural unfinished due to problems with getting paid by his employer and more importantly by his choice of technique, which instead of the fresco technique he experimented again (as in the Last Supper) with